The Role of Macrophage Lipophagy in Reverse Cholesterol Transport

The Role of Macrophage Lipophagy in Reverse Cholesterol Transport

Blog Article

Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis.Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that Bridle set regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes.In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target ULTIMATE 3-6-9 1200MG in the treatment of atherosclerosis.